Potent inhibitors of the map kinase p38

被引：47

作者：

Henry, JR ^{[1
]}

Rupert, KC ^{[1
]}

Dodd, JH ^{[1
]}

Turchi, IJ ^{[1
]}

Wadsworth, SA ^{[1
]}

Cavender, DE ^{[1
]}

Schafer, PH ^{[1
]}

Siekierka, JJ ^{[1
]}

机构：

[1] RW Johnson Pharmaceut Res Inst, Drug Discovery, Raritan, NJ 08869 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 23期

关键词：

D O I：

10.1016/S0960-894X(98)00589-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The MAP kinase p38 plays a key role in the biosynthesis of the inflammatory cytokines TNF-alpha and IL-1. We have developed a novel series of potent p38 inhibitors that could lead to new methods of treatment for inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease, (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：3335 / 3340

页数：6

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