Metallated alpha-alkoxypropargyl and gamma-alkoxyallenyl derivatives: Applications in some aldol reactions towards diterpene synthesis

被引：14

作者：

Anies, C ^{[1
]}

Lallemand, JY ^{[1
]}

Pancrazi, A ^{[1
]}

机构：

[1] ECOLE POLYTECH,DCSO,CNRS,SYNTH ORGAN LAB,F-91128 PALAISEAU,FRANCE

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 31期

关键词：

D O I：

10.1016/0040-4039(96)01186-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The allenyl titanium 11a, prepared using Yamamoto's conditions reacted with different aldehydes 12a-c to produce the anti acetylenic diols 13a-c. In a synthetic approach to erigerol 1 this reaction was applied to the aldehyde 4 and the expected key intermediate 13d was obtained in 40% yield after removal of the THP group. During this study the alpha-alkoxypropargylstannane 14 and the alpha-alkoxyallenylstannane 15 were prepared in good yields alter transmetallation of the corresponding lithio derivatives 5b and 7b by Ti((OPr)-Pr-i)(4) or Et(2)ZnCl. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：5519 / 5522

页数：4

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