Phenolic constituents of Glycyrrhiza species.: Part 22 -: An isoprenylated flavanone from Glycyrrhiza glabra and REC-assay of licorice phenols

被引：30

作者：

Fukai, T ^{[1
]}

Cai, BS ^{[1
]}

Maruno, K ^{[1
]}

Miyakawa, Y ^{[1
]}

Konishi, M ^{[1
]}

Nomura, T ^{[1
]}

机构：

[1] Toho Univ, Fac Pharmaceut Sci, Chiba 2748510, Japan

来源：

PHYTOCHEMISTRY | 1998年 / 49卷 / 07期

关键词：

Glycyrrhiza glabra; Fabaceae; licorice; kanzoh; roots; prenylated pyranoflavanone; kanzonol Z; kanzonol Y; absolute structure; rec-assay; Bacillus subtilis;

D O I：

10.1016/S0031-9422(98)00389-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new prenylated 3-hydroxypyranoflavanone, kanzonol Z, was isolated from cultivated licorice, Glycyrrhiza glabra, and the structure elucidated from spectral evidence. The stereochemical structure of kanzonol Y previously isolated from the licorice has been shown to be (alpha R)-3,5'-diprenyl-alpha,2',4,4'-tetra-hydroxydihydrochalcone by Mosher's method. In a prescreening test for bioactive compounds amongst licorice phenols using a recombinationless mutant of Bacillus subtilis M45, seven compounds showed induction activities of DNA damage. (C) 1998 Elsevier Science Ltd. All rights reserved

引用

页码：2005 / 2013

页数：9

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