Method to introduce stable, expanded, polyglutamine-encoding CAG/CAA trinucleotide repeats into CAG repeat-containing genes

被引：11

作者：

Michalik, A

Kazantsev, A

Van Broeckhoven, C

机构：

[1] Univ Instelling Antwerp, Mol Genet Lab, Dept Biochem, B-2610 Wilrijk, Belgium

[2] MIT, Cambridge, MA 02139 USA

来源：

BIOTECHNIQUES | 2001年 / 31卷 / 02期

关键词：

D O I：

10.2144/01312bm02

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

[No abstract available]

引用

页码：250 / +

页数：3

共 10 条

[1] Fourteen and counting: unraveling trinucleotide repeat diseases [J].

Cummings, CJ ;

Zoghbi, HY .

HUMAN MOLECULAR GENETICS, 2000, 9 (06) :909-916

[2] Betaine improves the PCR amplification of GC-rich DNA sequences [J].

Henke, W ;

Herdel, K ;

Jung, K ;

Schnorr, D ;

Loening, SA .

NUCLEIC ACIDS RESEARCH, 1997, 25 (19) :3957-3958

[3] Polyglutamine length-dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: their role in suppression of aggregation and cellular toxicity [J].

Jana, NR ;

Tanaka, M ;

Wang, GH ;

Nukina, N .

HUMAN MOLECULAR GENETICS, 2000, 9 (13) :2009-2018

[4] EXPANSION AND DELETION OF CTG REPEATS FROM HUMAN-DISEASE GENES ARE DETERMINED BY THE DIRECTION OF REPLICATION IN ESCHERICHIA-COLI [J].

KANG, S ;

JAWORSKI, A ;

OHSHIMA, K ;

WELLS, RD .

NATURE GENETICS, 1995, 10 (02) :213-218

[5] Insoluble detergent-resistant aggregates form between pathological and nonpathological lengths of polyglutamine in mammalian cells [J].

Kazantsev, A ;

Preisinger, E ;

Dranovsky, A ;

Goldgaber, D ;

Housman, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (20) :11404-11409

[6]

Laccone F, 1999, HUM MUTAT, V13, P497, DOI 10.1002/(SICI)1098-1004(1999)13:6<497::AID-HUMU10>3.0.CO

[7]

2-6

[8] Neurological abnormalities in a knock-in mouse model of Huntington's disease [J].

Lin, CH ;

Tallaksen-Greene, S ;

Chien, WM ;

Cearley, JA ;

Jackson, WS ;

Crouse, AB ;

Ren, SR ;

Li, XJ ;

Albin, RL ;

Detloff, PJ .

HUMAN MOLECULAR GENETICS, 2001, 10 (02) :137-144

[9] Instability of highly expanded CAG repeats in mice transgenic for the Huntington's disease mutation [J].

Mangiarini, L ;

Sathasivam, K ;

Mahal, A ;

Mott, R ;

Seller, M ;

Bates, GP .

NATURE GENETICS, 1997, 15 (02) :197-200

[10] Preparation of human cDNAs encoding expanded polyglutamine repeats [J].

Peters, MF ;

Ross, CA .

NEUROSCIENCE LETTERS, 1999, 275 (02) :129-132

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