Gender differences and endothelium- and platelet-derived factors in the coronary circulation

被引:35
作者
Miller, VM
Lewis, DA
Barber, DA
机构
[1] Mayo Clin & Mayo Fdn, Dept Surg, Rochester, MN 55905 USA
[2] Mayo Clin & Mayo Fdn, Dept Physiol & Biophys, Rochester, MN 55905 USA
[3] Mayo Clin & Mayo Fdn, Dept Internal Med, Rochester, MN 55905 USA
[4] Pikeville Coll Sch Osteopath Med, Dept Physiol & Pharmacol, Pikeville, KY USA
关键词
adenosine diphosphate; 5-hydroxytryptamine; oestrogen; platelet-derived growth factor; prostacyclin; thromboxane;
D O I
10.1046/j.1440-1681.1999.02997.x
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
1. Experiments were designed to determine whether or not interactions of platelets with coronary arteries are affected by gender or oestrogen-status. 2. Platelets and right coronary arteries were isolated from sexually mature male, female and ovariectomized pigs. Arteries were suspended in organ chambers for the measurement of isometric force. Responses of rings, with and without endothelium, were evaluated to aggregating platelets and the platelet products 5-hydroxytryptamine (5-HT) and adenosine diphosphate (ADP). 3. Release of 5-HT, thromboxane A(2) (TXA(2)) and prostacyclin were measured from platelets. 4. Platelets caused relaxations of rings with endothelium from all pigs. However, in rings without endothelium, consistent contractions were observed only in rings from male pigs. 5. The release of 5-HT and prostacyclin was greatest from platelets of ovariectomized pigs compared with male and female pigs. Release of TXA(2) was greatest from platelets of male pigs. 6. Endothelium-dependent relaxations to ADP and contractions to 5-HT Here similar among the three groups. 7. These results suggest that there may be gender-specific differences in vasomotor responses to autogenous platelets but not to the platelet-derived products 5-HT and ADP. Furthermore, there are gender differences in platelets in the release of cyclooxygenase metabolites of arachidonic acid and 5-HT. These products could contribute to gender differences in response to injury in the coronary circulation.
引用
收藏
页码:132 / 136
页数:5
相关论文
共 36 条
  • [21] HOUSTON DS, 1985, AM J PHYSIOL, V248, P389
  • [22] Estrogen inhibits the vascular injury response in estrogen receptor alpha-deficient mice
    Iafrati, MD
    Karas, RH
    Aronovitz, M
    Kim, S
    Sullivan, TR
    Lubahn, DB
    ODonnell, TF
    Korach, KS
    Mendelsohn, ME
    [J]. NATURE MEDICINE, 1997, 3 (05) : 545 - 548
  • [23] GLOMERULAR ATRIAL-NATRIURETIC-FACTOR RECEPTORS IN EXPERIMENTAL CONGESTIVE-HEART-FAILURE
    ISNARD, R
    CARAYON, A
    EURIN, J
    MAISTRE, G
    BOUANANI, N
    BARTHELEMY, C
    CROZATIER, B
    KOMAJDA, M
    LEGRAND, JC
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1993, 265 (03): : H923 - H928
  • [24] KNIGHTON DR, 1990, SURG GYNECOL OBSTET, V170, P56
  • [25] ROLE OF PLATELET-DERIVED GROWTH-FACTOR IN WOUND-HEALING - SYNERGISTIC EFFECTS WITH OTHER GROWTH-FACTORS
    LYNCH, SE
    NIXON, JC
    COLVIN, RB
    ANTONIADES, HN
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (21) : 7696 - 7700
  • [26] TESTOSTERONE INCREASES THROMBOXANE A(2) RECEPTOR DENSITY AND RESPONSIVENESS IN RAT AORTAS AND PLATELETS
    MATSUDA, K
    RUFF, A
    MORINELLI, TA
    MATHUR, RS
    HALUSHKA, PV
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1994, 267 (03): : H887 - H893
  • [27] AGGREGATING PLATELETS CONTRACT ISOLATED CANINE PULMONARY-ARTERIES BY RELEASING 5-HYDROXYTRYPTAMINE
    MCGOON, MD
    VANHOUTTE, PM
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1984, 74 (03) : 828 - 833
  • [28] PARADOXICAL INFLUENCE OF ESTROGENIC HORMONES ON PLATELET-ENDOTHELIAL CELL-INTERACTIONS
    MILLER, ME
    DORES, GM
    THORPE, SL
    AKERLEY, WL
    [J]. THROMBOSIS RESEARCH, 1994, 74 (06) : 577 - 594
  • [29] 17-BETA-ESTRADIOL AUGMENTS ENDOTHELIUM-DEPENDENT CONTRACTIONS TO ARACHIDONIC-ACID IN RABBIT AORTA
    MILLER, VM
    VANHOUTTE, PM
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1990, 258 (06): : R1502 - R1507
  • [30] MILLER VM, 1992, STEROID HORMONES AND UTERINE BLEEDING, P299