NCAM-induced intracellular signaling revisited

被引：135

作者：

Ditlevsen, Dorte Kornerup ^{[1
,2
]}

Povlsen, Gro Klitgaard ^{[1
,2
]}

Berezin, Vladimir ^{[1
]}

Bock, Elisabeth ^{[1
]}

机构：

[1] Univ Copenhagen, Panum Inst, Inst Neurosci & Pharmacol, Protein Lab, DK-2200 Copenhagen, Denmark

[2] Enkam Pharmaceut AS, Copenhagen, Denmark

来源：

JOURNAL OF NEUROSCIENCE RESEARCH | 2008年 / 86卷 / 04期

关键词：

cell adhesion molecule; fibroblast growth factor receptor; neuronal differentiation; signal transduction;

D O I：

10.1002/jnr.21551

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The neural cell adhesion molecule (NCAM) plays a crucial role in neuronal development, synaptic plasticity, and regeneration. NCAM works as "smart glue" that not only mediates cell-cell adhesion but also induces activation of a complex network of intracellular signaling cascades on homophilic or heterophilic binding. Stimulation of NCAM by homophilic interactions induces neuronal differentiation through activation of a number of signaling molecules, including the fibroblast growth factor receptor, non-receptor kinases Fyn and focal adhesion kinase, growth-associated protein-43, the mitogen-activated protein kinase pathway, intracellular Ca2+, and protein kinases A, C, and G. This review presents and discusses the current knowledge in the area of NCAM signaling with a focus on the events involved in NCAM-mediated neurite outgrowth. (c) 2007 Wiley-Liss, Inc.

引用

页码：727 / 743

页数：17

共 113 条

[91] Prion protein recruits its neuronal receptor NCAM to lipid rafts to activate p59fyn and to enhance neurite outgrowth [J].