Extracts of Phellinus gilvus and Phellinus baumii inhibit pulmonary inflammation induced by lipopolysaccharide in rats

被引：81

作者：

Jang, BS

Kim, JC

Bae, JS

Rhee, MH

Jang, KH

Song, JC

Kwon, OD

Park, SC ^{[1
]}

机构：

[1] Kyungpook Natl Univ, Coll Vet Med, Taegu, South Korea

[2] Chungnam Natl Univ, Coll Vet Med, Taejon, South Korea

[3] Chonnam Natl Univ, Coll Vet Med, Gwangju, South Korea

来源：

BIOTECHNOLOGY LETTERS | 2004年 / 26卷 / 01期

关键词：

inflammation; neutrophilia; Phellinus baumii; Phellinus gilvus; rats;

D O I：

10.1023/B:BILE.0000009456.63616.32

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Compared to saline-challenged rats, rats exposed to 50 mug intratracheal lipopolysaccharide showed an increase of total white cells (from 0.3 x 10(6) to 2.4 x 10(6)), neutrophils (from 0.09 x 10(6) to 1.8 x 10(6)), the levels of tumor necrosis factor (TNF)-alpha (from 200 pg ml(-1) to 1200 pg ml(-1)), and interleukin (IL)-1beta (from 220 pg ml(-1) to 650 pg ml(-1)) in the bronchial lavage fluid. However, after pretreatment with extracts of Phellinus gilvus and Phellinus baumii, the total white cells, neutrophils, and the level of IL-1beta in lipopolysaccharide-challenged rats were similar to those in saline-challenged rats, except for TNF-alpha. The results indicate that extracts of P. gilvus and P. baumii may be useful in preventing acute pulmonary inflammation in human diseases.

引用

页码：31 / 33

页数：3

共 8 条

[1] Antioxidant and antihepatotoxic activities of Phellinus rimosus (Berk) Pilat [J].