Transposons for cancer gene discovery: Sleeping Beauty and beyond

被引：20

作者：

Collier, Lara S. ^{[1
]}

Largaespada, David A. ^{[1
]}

机构：

[1] Univ Minnesota Twin Cities, Ctr Canc, Dept Genet Cell Biol & Dev, Minneapolis, MN 55455 USA

来源：

GENOME BIOLOGY | 2007年 / 8卷

关键词：

D O I：

10.1186/gb-2007-8-S1-S15

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The use of Sleeping Beauty transposons as somatic mutagens to discover cancer genes in hematopoietic tumors and sarcomas has been documented. Here, we discuss the future of Sleeping Beauty for cancer genetic studies and the potential use of additional transposable elements for somatic mutagenesis.

引用

页数：8

共 59 条

[1] Active retrotransposition by a synthetic L1 element in mice [J].

An, Wenfeng ;

Han, Jeffrey S. ;

Wheelan, Sarah J. ;

Davis, Edward S. ;

Coombes, Candice E. ;

Ye, Ping ;

Triplett, Christina ;

Boeke, Jef D. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (49) :18662-18667

[2] L1 integration in a transgenic mouse model [J].

Babushok, DV ;

Ostertag, EM ;

Courtney, CE ;

Choi, JM ;

Kazazian, HH .

GENOME RESEARCH, 2006, 16 (02) :240-250

[3] Harnessing a high cargo-capacity transposon for genetic applications in vertebrates [J].

Balciunas, Darius ;

Wangensteen, Kirk J. ;

Wilber, Andrew ;

Bell, Jason ;

Geurts, Aron ;

Sivasubbu, Sridhar ;

Wang, Xin ;

Hackett, Perry B. ;

Largaespada, David A. ;

McIvor, R. Scott ;

Ekker, Stephen C. .

PLOS GENETICS, 2006, 2 (11) :1715-1724

[4] Transposons reanimated in mice [J].

Bestor, TH .

CELL, 2005, 122 (03) :322-325

[5]

Carlson CM, 2003, GENETICS, V165, P243

[6] Hopping around the tumor genome: Transposons for cancer gene discovery [J].

Collier, LS ;

Largaespada, DA .

CANCER RESEARCH, 2005, 65 (21) :9607-9610

[7] Cancer gene discovery in solid tumours using transposon-based somatic mutagenesis in the mouse [J].

Collier, LS ;

Carlson, CM ;

Ravimohan, S ;

Dupuy, AJ ;

Largaespada, DA .

NATURE, 2005, 436 (7048) :272-276

[8] Efficient transposition of the piggyBac resource (PB) transposon in mammalian cells and mice [J].

Ding, S ;

Wu, XH ;

Li, G ;

Han, M ;

Zhuang, Y ;

Xu, T .

CELL, 2005, 122 (03) :473-483

[9] Transposition of the Drosophila hydei Minos transposon in the mouse germ line [J].

Drabek, D ;

Zagoraiou, L ;

deWit, T ;

Langeveld, A ;

Roumpaki, C ;

Mamalaki, C ;

Savakis, C ;

Grosveld, F .

GENOMICS, 2003, 81 (02) :108-111

[10] Sleeping beauty: a novel cancer gene discovery tool [J].

Dupuy, AJ ;

Jenkins, NA ;

Copeland, NG .

HUMAN MOLECULAR GENETICS, 2006, 15 :R75-R79

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