Transposons for cancer gene discovery: Sleeping Beauty and beyond

被引：20

作者：

Collier, Lara S. ^{[1
]}

Largaespada, David A. ^{[1
]}

机构：

[1] Univ Minnesota Twin Cities, Ctr Canc, Dept Genet Cell Biol & Dev, Minneapolis, MN 55455 USA

来源：

GENOME BIOLOGY | 2007年 / 8卷

关键词：

D O I：

10.1186/gb-2007-8-S1-S15

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The use of Sleeping Beauty transposons as somatic mutagens to discover cancer genes in hematopoietic tumors and sarcomas has been documented. Here, we discuss the future of Sleeping Beauty for cancer genetic studies and the potential use of additional transposable elements for somatic mutagenesis.

引用

页数：8

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