Fibroblast biology - Effector signals released by the synovial fibroblast in arthritis

被引:133
作者
Ritchlin, C [1 ]
机构
[1] Univ Rochester, Med Ctr, Clin Immunol & Rheumatol Unit, Rochester, NY 14642 USA
关键词
chemokines; cytokines; effector cell; rheumatoid arthritis; synovial fibroblast; synovial membrane;
D O I
10.1186/ar112
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
There is mounting evidence indicating that the synovial fibroblast is a direct effector of tissue injury and matrix remodeling in inflammatory synovitis. Through the elaboration of effector signals including cytokines and chemokines, mesenchymal cells stimulate or suppress inflammation via autocrine and paracrine mechanisms. Synovial fibroblasts are the principal cells mediating joint destruction through secretion of metalloproteinases, and recent evidence suggests that they may also promote bone resorption by stimulating osteoclastogenesis. Moreover, they may play an integral role in the initial phases of synovitis by releasing chemokines that recruit leukocytes to the joint, and cytokines that trigger angiogenesis. Studies focusing on synoviocyte-leukocyte interactions mediated via the cytokine network and the role of cell-cell contact in driving synoviocyte activation will help define the complex interplay that leads to the initiation and perpetuation of synovial inflammation.
引用
收藏
页码:356 / 360
页数:5
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