The effects of some pesticites on the activity of liver and erythrocyte enzymes (in vitro)

The effect of pomarsol (tetramethyltriurem disulphide), Benlate 1-(N-Butlycarbomoyl) 2-(Metoxycarboxamido)-bezimidazol, meothrin (alpha-cyanophenoxbenzyl 2.2.3.3.-tetramethyl cyclopropanecarbonylate), Imperator [alpha-cyano 3-phenoxybenzyl-cis, trans-3- (2.2-dichroinyl)-2.2- dimetil research on GOT, GPT (liver enzymes) and CA-I, CA-II (Human erythrocyt) BCA (Bovine erythrocyt). Among the chemicals meothrin, imperator, sumicidin were determined to have inhibitory effect, on bovine CA, human CA and GOT enzymes, but ineffective on GPT enzyme. The I-50 values of chemicals caused inhibition were determined by means of activity percentage [I] diagrams. The values were 3.2x10(-2) M, 3.5x10(-2) M, 2.7x10(-2) M for GOT respectively. The values of same chemicals were 5.8x10(-3) M, 1.00x10(-2) M, 1.22x10(-2) M for CA-I, and 7.11x10(-3) M, 2.68x10(-2) M, 1.22x10(-2) M for CA-II respectively on the order nand, these chemical were 9.25x10(-3) M, 8.65x10(-3) M and 1.63x10(-2) M for bovine CA.