A rodent model of schizophrenia reveals increase in creatine kinase activity with associated behavior changes

被引：29

作者：

Canever, Leila ^{[1
]}

Oliveira, Larissa ^{[1
]}

de Luca, Renata D'Altoe ^{[1
]}

Correa, Paulo T. F. ^{[1
]}

Fraga, Daiane de B. ^{[1
]}

Matos, Maria Paula ^{[1
]}

Scaini, Giselli ^{[2
,3
]}

Quevedo, Joao ^{[1
]}

Streck, Emilio L. ^{[2
,3
]}

Zugno, Alexandra I. ^{[1
]}

机构：

[1] Univ Extremo Catarinense, Unidade Acad Ciencias Saude, Programa Posgrad Ciencias Saude, Lab Neurociencias, Criciuma, SC, Brazil

[2] Univ Extremo Catarinense, Unidade Acad Ciencias Saude, Programa Posgrad Ciencias Saude, Lab Fisiopatol Expt, Criciuma, SC, Brazil

[3] Univ Extremo Catarinense, Unidade Acad Ciencias Saude, Programa Posgrad Ciencias Saude, INCT TM, Criciuma, SC, Brazil

来源：

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY | 2010年 / 3卷 / 06期

关键词：

brain; ketamine; schizophrenia; creatine kinase; behavioral; energy metabolism; KETAMINE-INDUCED CHANGES; POSSIBLE ANIMAL-MODEL; OXIDATIVE STRESS; RAT BEHAVIOR; BRAIN; EXPRESSION; INHIBITION; AUTISM; MICE; NEUROBIOLOGY;

D O I：

10.4161/oxim.3.6.13446

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Schizophrenia is a debilitating mental disorder characterized by positive (delusions, hallucinations, disorganized speech) and negative (affective flattering, avolition and social withdrawal) symptoms as well as cognitive deficit!;. The frequency, severity and topography characterize the disorder as heterogeneous, the pathophysiology of schizophrenia is poorly understood. Sub-anesthetic doses of ketamine produce hyperactivity, stereotypy and abnormal social interaction and it is used as a model of schizophrenia. In this study, we induced an animal model by acute sub-anesthetic doses of ketamine and tested different behavioral parameters. We also evaluated the activity of creatine kinase (CK) in brain of rats treated with ketamine. Our results demonstrated that administration of 10,25 and 50 mg/kg of ketamine induced an increase of covered distance in habituated and non-habituated rats to the behavioral apparatus. Ketamine administration induced significant social deficits and stereotypic behavioral in all doses tested. Finally we evaluated the effect cf different doses of ketamine on creatinine kinase (CK) activity and we observed that CK activity is increased inspecific regions of the brain. Our study suggests that our animal model may be used as a model of schizophrenia and that cerebral energy metabolism might be altered in the brain of schizophrenic patients, probably leading to alterations that might be involved in the pathogenesis of schizophrenia.

引用

页码：421 / 427

页数：7

共 64 条

[61] INTRACELLULAR COMPARTMENTATION, STRUCTURE AND FUNCTION OF CREATINE-KINASE ISOENZYMES IN TISSUES WITH HIGH AND FLUCTUATING ENERGY DEMANDS - THE PHOSPHOCREATINE CIRCUIT FOR CELLULAR-ENERGY HOMEOSTASIS [J].