Campath-1H as rescue therapy for the treatment of acute rejection in kidney transplant patients

被引:34
作者
Csapo, Z [1 ]
Benavides-Viveros, C [1 ]
Podder, H [1 ]
Kahan, BD [1 ]
机构
[1] Univ Texas, Sch Med, Div Immunol & Organ Transplantat, Houston, TX 77030 USA
关键词
D O I
10.1016/j.transproceed.2005.03.042
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Introduction. Yidney transplant patients with acute rejection episodes refractory to antilymphocyte preparations require aggressive treatment to salvage renal function and reduce the progression of chronic allograft nephropathy. Patients and methods. During a 6-month period, we administered Campath-1H as salvage therapy to five patients who had been previously treated with thymoglobulin and/or OKT3. In addition to measurements of the serum creatinine and BUN levels, we estimated creatinine clearance and glomerular filtration rates (GFR) using the Cockcroft-Gault and the MDRD equations at the time of initiation of therapy as well as at 2 weeks and 2 months thereafter. Result. Four of the five patients responded to Campath-1H therapy; kidney function improved to nearly the level before the rejection episode. The estimated creatinine clearance increased approximately threefold and the GFR approximately fourfold higher than the values before Campath-1H administration. The adverse events were mild and self-limited. Conclusion. Salvage of refractory acute rejection episodes may be possible in selected patients using Campath-1H.
引用
收藏
页码:2032 / 2036
页数:5
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