Oseltamivir and Risk of Lower Respiratory Tract Complications in Patients With Flu Symptoms: A Meta-analysis of Eleven Randomized Clinical Trials

被引：92

作者：

Hernan, Miguel A. ^{[1
,2
]}

Lipsitch, Marc ^{[1
,3
,4
]}

机构：

[1] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Publ Hlth, Harvard MIT Div Hlth Sci & Technol, Boston, MA 02115 USA

[3] Harvard Univ, Sch Publ Hlth, Ctr Communicable Dis Dynam, Boston, MA 02115 USA

[4] Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA

来源：

CLINICAL INFECTIOUS DISEASES | 2011年 / 53卷 / 03期

关键词：

NEURAMINIDASE INHIBITORS; ACUTE INFLUENZA; SAFETY; EFFICACY;

D O I：

10.1093/cid/cir400

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

An independent reanalysis of 11 randomized clinical trials shows that oseltamivir treatment reduces the risk of lower respiratory tract complications requiring antibiotic treatment by 28% overall (95% confidence interval [CI], 11%-42%) and by 37% among patients with confirmed influenza infections (95% CI, 18%-52%).

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页码：277 / 279

页数：3

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