Anti-inflammatory effect of virgin olive oil in stable coronary disease patients:: a randomized, crossover, controlled trial

被引：125

作者：

Fito, M. ^{[1
]}

Cladellas, M. ^{[2
]}

de la Torre, R. ^{[3
,4
]}

Marti, J. ^{[2
]}

Munoz, D. ^{[1
]}

Schroder, H. ^{[1
]}

Alcantara, M. ^{[1
]}

Pujadas-Bastardes, M. ^{[3
]}

Marrugat, J. ^{[1
]}

Lopez-Sabater, M. C. ^{[5
]}

Bruguera, J. ^{[2
]}

Covas, M. I. ^{[1
]}

机构：

[1] Hosp Mar, Inst Municipal Invest Med, Unitat Lipids & Epidemiol Cardiovasc, PRBB, Barcelona 08003, Spain

[2] Hosp Mar, Serv Cardiol, Barcelona 08003, Spain

[3] Inst Municipal Invest Med, Unitat Recerca Farmacol, E-08003 Barcelona, Spain

[4] Univ Pompeu Fabra, Barcelona, Spain

[5] Fac Farm Barcelona, Unitat Nutr & Bromatol, Barcelona, Spain

来源：

EUROPEAN JOURNAL OF CLINICAL NUTRITION | 2008年 / 62卷 / 04期

关键词：

olive oil; phenolic compounds; inflammation; interleukins; coronary heart disease;

D O I：

10.1038/sj.ejcn.1602724

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Objectives: To assess the effect of two similar olive oils, but with differences in their phenolic compounds ( powerful antioxidant compounds), on inflammatory markers in stable coronary heart disease patients. Design: Placebo-controlled, crossover, randomized trial. Setting: Cardiology Department of Hospital del Mar and Institut Municipal d'Investigacio Medica ( Barcelona). Subjects: Twenty- eight stable coronary heart disease patients. Interventions: A raw daily dose of 50 ml of virgin and refined olive oil ( ROO) was sequentially administered over two periods of 3- weeks, preceded by 2- week washout periods in which ROO was used. Results: Interleukin- 6 ( P<0.002) and C- reactive protein ( P= 0.024) decreased after virgin olive oil intervention. No changes were observed in soluble intercellular and vascular adhesion molecules, glucose and lipid profile. Conclusions: Consumption of virgin olive oil, could provide beneficial effects in stable coronary heart disease patients as an additional intervention to the pharmacological treatment.

引用

页码：570 / 574

页数：5

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