Ganglioside/protein kinase signals triggering cytoskeletal actin reorganization

被引：24

作者：

Higashi, H

Chen, NH

机构：

[1] Mitsubishi Kagaku Inst Life Sci, Tokyo 1948511, Japan

[2] Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China

[3] Peking Union Med Coll, Beijing 100050, Peoples R China

来源：

GLYCOCONJUGATE JOURNAL | 2003年 / 20卷 / 01期

关键词：

ganglioside; CaMKII; A-kinase; N-acetylgalactosamine; dendritogenesis;

D O I：

10.1023/B:GLYC.0000016742.88750.1a

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Exposure of neuronal cells to nanomolar concentrations of oligosaccharide portions of ganglioside GM2 and GT1b stimulates cAMP-dependent protein kinase (PKA) and Ca2+/calmodulin-dependent protein kinase II ( CaMKII), respectively, in a few seconds suggesting the presence of glyco-receptor-like molecules on the surface of the cells. Both GM2/PKA (GalNAc/PKA) and GT1b/CaMKII signaling cascades induced cytoskeletal actin reorganization through Cdc42 activation leading to filopodia formation within 2 min. Long-term effects of these glyco-signals were facilitation of dendritic differentiation of primary cultured hippocampal neurons and cerebellar Purkinje neurons indicating physiological roles of the signals in neuronal differentiation and maturation.

引用

页码：49 / 58

页数：10

共 88 条

[51] ACTIVATION OF PROTEIN-KINASE-C BY GANGLIOSIDE GM3 IN THE PRESENCE OF CALCIUM AND 12-O-TETRADECANOYLPHORBOL-13-ACETATE [J].