The TSH receptor and thyroid diseases

被引:11
作者
Paschke, R [1 ]
VanSande, J [1 ]
Parma, J [1 ]
Vassart, G [1 ]
机构
[1] FREE UNIV BRUSSELS, SERV GENET MED, B-1070 BRUSSELS, BELGIUM
来源
BAILLIERES CLINICAL ENDOCRINOLOGY AND METABOLISM | 1996年 / 10卷 / 01期
关键词
D O I
10.1016/S0950-351X(96)80266-7
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Recent advances in the understanding of the molecular biology of the TSH receptor have had a considerable impact on several aspects of thyroidology. The identification and functional characterization of mutations in the TSH receptor gene which constitutively activate the TSH receptor in the absence of its ligand provide an explanation for the molecular mechanism which is most likely responsible for the majority of the hyperfunctioning thyroid adenomas. Moreover, these constitutively activating mutations also cause a new form of familial hyperthyroidism: non-autoimmune autosomal dominant hyperthyroidism and also sporadic cases of congenital non-autoimmune hyperthyroidism. TSH receptor mutations which cause a reduced sensitivity to TSH have been identified as the cause of non-autoimmune congenital hypothyroidism. TSH receptor mRNA variants have been found in thyroid associated ophthalmopathy. If protein expression for these variants can be demonstrated, this finding could advance our understanding of thyroid associated ophthalmopathy. The ability to produce large quantities of TSH receptor protein in bacteria has led to the generation of more sophisticated assays for TSH receptor antibodies and enabled the generation of an animal model for thyroid autoimmunity.
引用
收藏
页码:9 / 27
页数:19
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