A protective and broadly cross-neutralizing epitope of human papillomavirus L2

被引:183
作者
Gambhira, Ratish [1 ]
Karanam, Balasubramanyam [1 ]
Jagu, Subhashini [1 ]
Roberts, Jeffrey N. [4 ]
Buck, Christopher B. [4 ]
Bossis, Ioannis [1 ]
Alphs, Hannah [1 ]
Culp, Timothy [5 ]
Christensen, Neil D. [5 ]
Roden, Richard B. S. [1 ,2 ,3 ]
机构
[1] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21231 USA
[2] Johns Hopkins Univ, Sch Med, Dept Oncol, Baltimore, MD 21231 USA
[3] Johns Hopkins Univ, Sch Med, Dept Gynecol & Obstet, Baltimore, MD 21231 USA
[4] NCI, Cellular Oncol Lab, Bethesda, MD 20892 USA
[5] Penn State Univ, Coll Med, Dept Microbiol & Immunol, Hershey, PA USA
关键词
D O I
10.1128/JVI.00936-07
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
We generated a monoclonal antibody, RG-1, that binds to highly conserved L2 residues 17 to 36 and neutralizes human papillomavirus 16 (HPV16) and HPV18. Passive immunotherapy with RG-1 was protective in mice. Antiserum to the HPV16 L2 peptide comprising residues 17 to 36 (peptide 17-36) neutralized pseudoviruses HPV5, HPV6, HPV16, HPV 18, HPV31, HPV 45, HPV 52, HPV 58, bovine papillomavirus 1, and HPV11 native virions. Depletion of HPV16 L2 peptide 17-36-reactive antibodies from cross-neutralizing rabbit and human L2-specific sera abolished cross-neutralization and drastically reduced neutralization of the cognate type. This cross-neutralization of diverse HPVs associated with cervical cancer, genital warts, and epidermodysplasia verruciformis suggests the possibility of a broadly protective, peptide-based vaccine.
引用
收藏
页码:13927 / 13931
页数:5
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