Atorvastatin and Aβ(1-40): Not as Simple as Cholesterol Reduction in Brain and Relevance to Alzheimer Disease

被引：10

作者：

Butterfield, D. Allan ^{[1
,2
]}

机构：

[1] Univ Kentucky, Ctr Membrane Sci, Dept Chem, Lexington, KY 40506 USA

[2] Univ Kentucky, Sanders Brown Ctr Aging, Lexington, KY 40506 USA

来源：

EXPERIMENTAL NEUROLOGY | 2011年 / 228卷 / 01期

关键词：

HMG-COA REDUCTASE; NITRIC-OXIDE SYNTHASE; CELLULAR STRESS-RESPONSE; TRANSGENIC MOUSE MODEL; CENTRAL-NERVOUS-SYSTEM; A-BETA ACCUMULATION; OXIDATIVE STRESS; AMYLOID-BETA; STATIN THERAPY; LIPID-PEROXIDATION;

D O I：

10.1016/j.expneurol.2010.12.014

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

引用

页码：15 / 18

页数：4

共 86 条

[51] Changes in apolipoprotein E expression in response to dietary and pharmacological modulation of cholesterol [J].

Petanceska, SS ;

DeRosa, S ;

Sharma, A ;

Diaz, N ;

Duff, K ;

Tint, SG ;

Refolo, LM ;

Pappolla, M .

JOURNAL OF MOLECULAR NEUROSCIENCE, 2003, 20 (03) :395-406

[52] Statin therapy for Alzheimer's disease - Will it work? [J].

Petanceska, SS ;

DeRosa, S ;

Olm, V ;

Diaz, N ;

Sharma, A ;

Thomas-Bryant, T ;

Duff, K ;

Pappolla, M ;

Refolo, LM .

JOURNAL OF MOLECULAR NEUROSCIENCE, 2002, 19 (1-2) :155-161

[53] Atorvastatin prevents hippocampal cell death, neuroinflammation and oxidative stress following amyloid-β1-40 administration in mice: Evidence for dissociation between cognitive deficits and neuronal damage [J].

Piermartiri, Tetsade C. B. ;

Figueiredo, Claudia P. ;

Rial, Daniel ;

Duarte, Filipe S. ;

Bezerra, Sarah C. ;

Mancini, Gianni ;

de Bern, Andreza F. ;

Prediger, Rui D. S. ;

Tasca, Carla I. .

EXPERIMENTAL NEUROLOGY, 2010, 226 (02) :274-284

[54] The neurobiology of isoprostanes and Alzheimer's disease [J].

Pratico, Domenico .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2010, 1801 (08) :930-933

[55] Statin use and the risk of incident dementia - The cardiovascular health study [J].

Rea, TD ;

Breitner, JC ;

Psaty, BM ;

Fitzpatrick, AL ;

Lopez, OL ;

Newman, AB ;

Hazzard, WR ;

Zandi, PP ;

Burke, GL ;

Lyketsos, CG ;

Bernick, C ;

Kuller, LH .

ARCHIVES OF NEUROLOGY, 2005, 62 (07) :1047-1051

[56] A cholesterol-lowering drug reduces β-amyloid pathology in a transgenic mouse model of Alzheimer's disease [J].

Refolo, LM ;

Pappolla, MA ;

LaFrancois, J ;

Malester, B ;

Schmidt, SD ;

Thomas-Bryant, T ;

Tint, GS ;

Wang, R ;

Mercken, M ;

Petanceska, SS ;

Duff, KE .

NEUROBIOLOGY OF DISEASE, 2001, 8 (05) :890-899

[57] Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model [J].

Refolo, LM ;

Pappolla, MA ;

Malester, B ;

LaFrancois, J ;

Bryant-Thomas, T ;

Wang, R ;

Tint, GS ;

Sambamurti, K ;

Duff, K .

NEUROBIOLOGY OF DISEASE, 2000, 7 (04) :321-331

[58]

Riekse RG, 2006, J ALZHEIMERS DIS, V10, P399

[59] Epidemiological and clinical trials evidence about a preventive role for statins in Alzheimer's disease [J].

Rockwood, K. .

ACTA NEUROLOGICA SCANDINAVICA, 2006, 114 :71-77

[60] Use of lipid-lowering agents, indication bias, and the risk of dementia in community-dwelling elderly people [J].

Rockwood, K ;

Kirkland, S ;

Hogan, DB ;

MacKnight, C ;

Merry, H ;

Verreault, R ;

Wolfson, C ;

McDowell, I .

ARCHIVES OF NEUROLOGY, 2002, 59 (02) :223-227

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