共 44 条
Structure of eukaryotic Mediator complexes
被引:140
作者:

Chadick, JZ
论文数: 0 引用数: 0
h-index: 0
机构:
Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA

Asturias, FJ
论文数: 0 引用数: 0
h-index: 0
机构:
Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA
机构:
[1] Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA
关键词:
D O I:
10.1016/j.tibs.2005.03.001
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
Mediator, a macromolecular complex comprising similar to 20 different protein components, is largely responsible for the tight control of transcription that underpins cell development, differentiation, and maintenance in eukaryotes from yeast to human. In the past five years, macromolecular electron microscopy has been used to characterize the structure of Mediator, and of the complexes it forms with other components of the transcription machinery. The results reveal how Mediator interacts with RNA polymerase II, and suggest that regulatory information could be conveyed through changes in Mediator conformation that would influence the transcription initiation process.
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页码:264 / 271
页数:8
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