Copper-catalyzed synthesis of enantioenriched tetraarylethanes

被引：18

作者：

Jen, Wendy S. ^{[1
]}

Truppo, Matthew D. ^{[1
]}

Amos, Deborah ^{[1
]}

Devine, Paul ^{[1
]}

McNevin, Michael ^{[1
]}

Biba, Mirlinda ^{[1
]}

Campos, Kevin R. ^{[1
]}

机构：

[1] Merck Res Labs, Dept Proc Res, Rahway, NJ 07065 USA

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 05期

关键词：

D O I：

10.1021/ol7027543

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein we report the asymmetric synthesis of 1,2-dipyridyl-1,2-diarylethanes via an unusual Cu(I)-catalyzed dimerization reaction. Subjection of a variety of enantioenriched substituted 2-pyridyl alcohols to a one-pot protocol generates the desired products in good yields and diastereoselectivities and with ee's up to >99%.

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收藏

页码：741 / 744

页数：4

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