Peptide-assisted synthesis of gold nanoparticles and their self-assembly

被引:68
作者
Bhattacharjee, RR
Das, AK
Haldar, D
Si, S
Banerjee, A [1 ]
Mandal, TK
机构
[1] Indian Assoc Cultivat Sci, Polymer Sci Unit, Kolkata 700032, W Bengal, India
[2] Indian Assoc Cultivat Sci, Dept Biol Chem, Kolkata 700032, W Bengal, India
关键词
gold-pepticle; bionanoconjugate; nanoparticles; self-assembly; pepticle-peptide interaction;
D O I
10.1166/jnn.2005.166
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A novel gold nanoparticle-tripeptide (GNP-tripeptide) conjugate was prepared by peptide in-situ redox technique at ambient temperature using a newly designed tripeptide. This new tripeptide was so designed that it has a C-terminus tyrosine residue, which reduced Au+3 to Au, and the terminally located free amino group was bound to the gold nanoparticle (GNP) surface resulting in highly stable Au colloids. The average diameter of the tripeptide-stabilized GNP is 8.7 +/- 2.3 nm. Tripeptide bound gold nanoparticles formed three-dimensional assemblies in the presence of an excess of similar or disimilar tripeptides. The aggregation of GNPs results in a red shift in the surface plasmon resonance from lambda(max) = 527 to 556 nm. The effect of the solvent, concentration, and nature of the tripeptides on the assembly process were investigated by TEM and UV-visible spectroscopy.
引用
收藏
页码:1141 / 1147
页数:7
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