The macrophage scavenger receptor CD163

被引：341

作者：

Fabriek, BO ^{[1
]}

Dijkstra, CD ^{[1
]}

van den Berg, TK ^{[1
]}

机构：

[1] Vrije Univ Amsterdam Med Ctr, Dept Mol Cell Biol & Immunol, NL-1007 MB Amsterdam, Netherlands

来源：

IMMUNOBIOLOGY | 2005年 / 210卷 / 2-4期

关键词：

Cd163; haptoglobin; hemoglobin; scavenger receptor cystein-rich; tissue macrophages;

D O I：

10.1016/j.imbio.2005.05.010

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Mature tissue macrophages form a first line of defense to recognize and eliminate potential pathogens; these specialized cells are capable of phagocytosis, degradation of self and foreign materials, establishment of cell-cell interactions, and the production of inflammatory mediators. Mature tissue macrophages express a variety of receptors, including the scavenger receptor cystein-rich (SRCR) superfamily members. CD163 is a member of the SRCR family class B and is expressed on most subpopulations of mature tissue macrophages. The best characterized function of CD163, which is essentially a homeostatic one, is related to the binding of Hemoglobin: Haptoglobin complexes. Furthermore, it has been suggested that CD 163 positive macrophages or the soluble form of CD 163 plays a role in the resolution of inflammation, as they are found in high numbers in inflamed tissue. (C) 2005 Elsevier GmbH. All rights reserved.

引用

页码：153 / 160

页数：8

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