Vasoactive intestinal polypeptide as mediator of asthma

被引：73

作者：

Groneberg, DA ^{[1
]}

Springer, J ^{[1
]}

Fischer, A ^{[1
]}

机构：

[1] Humboldt Univ, Biomed Res Ctr, Div Allery Res, Dept Pediat Pneumol & Immunol, D-13353 Berlin, Germany

来源：

PULMONARY PHARMACOLOGY & THERAPEUTICS | 2001年 / 14卷 / 05期

关键词：

asthma; vasoactive intestinal polypeptide; VIP; neurotransmitters; airways;

D O I：

10.1006/pupt.2001.0306

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Vasoactive intestinal polypeptide (VIP) is one of the most abundant, biologically active peptides found in the human lung. VIP is a likely neurotransmitter or neuromodulator of the inhibitory non-adrenergic non-cholinergic airway nervous system and influences many aspects of pulmonary biology. In human airways VIP-immunoreactive nerve fibres are present in the tracheobronchial airway smooth muscle layer, the walls of pulmonary and bronchial vessels and around submucosal glands. Next to its prominent bronchodilatory effects, VIP potently relaxes pulmonary vessels. The precise role of VIP in the pathogenesis of asthma is still uncertain. Although a therapy using the strong bronchodilatory effects of VIP would offer potential benefits, the rapid inactivation of the peptide by airway peptidases has prevented effective VIP-based drugs so far and non-peptide VIP-agonists did not reach clinical use. (C) 2001 Academic Press.

引用

页码：391 / 401

页数：11

共 159 条

[41]

FRANCIS SH, 1988, MOL PHARMACOL, V34, P506

[42]

FRANCONI GM, 1989, J PHARMACOL EXP THER, V248, P947

[43] VASOACTIVE INTESTINAL POLYPEPTIDE PROMOTES CYCLIC ADENOSINE-3',5'-MONOPHOSPHATE ACCUMULATION IN GUINEA-PIG TRACHEA [J].