The problems and promises of research into human immunology and autoimmune disease

被引：42

作者：

Roep, Bart ^{[1
]}

Buckner, Jane ^{[2
]}

Sawcer, Stephen ^{[3
]}

Toes, Rene ^{[4
]}

Zipp, Frauke ^{[5
]}

机构：

[1] Leiden Univ, Med Ctr, Natl Diabet Expert Ctr, Dept Immunohaematol & Blood Transfus, Leiden, Netherlands

[2] Benaroya Res Inst, Translat Res Program, Seattle, WA USA

[3] Univ Cambridge, Addenbrookes Hosp, Dept Clin Neurosci, Cambridge CB2 2QQ, England

[4] Leiden Univ, Med Ctr, Dept Rheumatol, Leiden, Netherlands

[5] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Univ Med Mainz, Klin & Poliklin Neurol, Mainz, Germany

来源：

NATURE MEDICINE | 2012年 / 18卷 / 01期

关键词：

GENOME-WIDE ASSOCIATION; CITRULLINATED PROTEIN ANTIBODY; TYPE-1; DIABETES-MELLITUS; PLACEBO-CONTROLLED TRIAL; MULTIPLE-SCLEROSIS; T-CELLS; RHEUMATOID-ARTHRITIS; NEUROMYELITIS-OPTICA; INTERFERON-BETA; LIGAND TRAIL;

D O I：

10.1038/nm.2626

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Translational research in autoimmunity is hampered by a number of hurdles, including a lack of knowledge regarding initiating and pathologically relevant autoantigens, the low frequency of autoreactive pathogenic B and T cells, difficulty in accessing the affected tissue, differences between self-reactive and pathogen-specific lymphocytes, a lack of etiologically relevant preclinical animal models and the heterogeneity of disease presentation. Given the need for biomarkers and new therapeutics, it is imperative that these hurdles be surmounted.

引用

页码：48 / 53

页数：6

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