To B or Not to B? B-cells and graft rejection

被引：50

作者：

Zarkhin, Valeriya ^{[1
]}

Li, Li ^{[1
]}

Sarwal, Minnie ^{[1
]}

机构：

[1] Stanford Univ, Dept Pediat, Stanford, CA 94305 USA

来源：

TRANSPLANTATION | 2008年 / 85卷 / 12期

关键词：

B-cells; acute rejection; graft survival; transplantation;

D O I：

10.1097/TP.0b013e318177793e

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

There is increasing evidence that various maturational stages of B-cells infiltrate various solid organ transplants undergoing acute rejection. The presence of immature CD20(+) and mature CD138(+) plasma cells associate with more aggressive and steroid-recalcitrant graft rejection and portend poor graft outcomes. Though associative, the causal role of B-cells in graft rejection remains to be better understood. This review discusses the possible roles of B-cells in graft rejection, whether involved as antigen presenting, as indirect effector, or antibody producing cells.

引用

页码：1705 / 1714

页数：10

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