NK cell TRAIL eliminates immature dendritic cells in vivo and limits dendritic cell vaccination efficacy

被引：162

作者：

Hayakawa, Y

Screpanti, V

Yagita, H

Grandien, A

Ljunggren, HG

Smyth, MJ

Chambers, BJ ^{[1
]}

机构：

[1] Huddinge Univ Hosp, Karolinska Inst, Dept Med, Ctr Infect Med, S-14186 Huddinge, Sweden

[2] Peter MacCallum Canc Ctr, Canc Immunol Program, Melbourne, Vic, Australia

[3] Juntendo Univ, Sch Med, Dept Immunol, Bunkyo Ku, Tokyo 113, Japan

[4] Karolinska Inst, Ctr Microbiol & Tumor Biol, Stockholm, Sweden

来源：

JOURNAL OF IMMUNOLOGY | 2004年 / 172卷 / 01期

关键词：

D O I：

10.4049/jimmunol.172.1.123

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent studies have implicated a possible role for NK cells in regulating dendritic cells (DC) in vitro. In the present study, we demonstrate that immature DC are rapidly eliminated by NK cells in vivo via a pathway dependent on the TNF-related apoptosis-inducing ligand (TRAIL). Elimination of NK cells and/or neutralization of TRAIL function during immunization with immature DC loaded with nonself or tumor Ags significantly enhanced T cell responses to these Ags and Ag-specific tumor immunity. These data suggested that NK cell TRAIL might regulate responses to vaccination by controlling the survival of Ag-loaded DC.

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页码：123 / 129

页数：7

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