MicroRNAs in malignant progression

被引：116

作者：

Ma, Li ^{[1
,2
]}

Weinberg, Robert A. ^{[1
,2
]}

机构：

[1] Whitehead Inst Biomed Res, Weinerg Lab, Cambridge, MA 02142 USA

[2] MIT, Dept Biol, Cambridge, MA USA

来源：

CELL CYCLE | 2008年 / 7卷 / 05期

关键词：

metastasis; microRNA; miR-10b; knockout; antagomir;

D O I：

10.4161/cc.7.5.5547

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A growing body of evidence suggests that certain microRNAs (miRNAs) play causal roles in tumorigenesis by regulating genes that control cellular processes such as cell cycle, apoptosis and differentiation. Lately, work in our laboratory has revealed that a specific miRNA can cause cancer cells to invade and metastasize. Here we review recent progress made in several laboratories concerning the roles played by miRNAs in cancer pathogenesis and metastatic spread, with the focus on the pro-metastatic microRNA, miR-10b and discuss the future directions and possibilities for clinical applications.

引用

页码：570 / 572

页数：3

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