A glycopolymer chaperone for fibroblast growth factor-2

被引：46

作者：

Guan, R

Sun, XL

Hou, SJ

Wu, PY

Chaikof, EL

机构：

[1] Emory Univ, Sch Med, Dept Surg, Atlanta, GA 30322 USA

[2] Emory Univ, Sch Med, Dept Biomed Engn, Atlanta, GA 30322 USA

[3] Georgia Inst Technol, Sch Chem Engn, Atlanta, GA 30332 USA

来源：

BIOCONJUGATE CHEMISTRY | 2004年 / 15卷 / 01期

关键词：

D O I：

10.1021/bc034138t

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Mono- and disaccharide-containing glycopolymers were synthesized by cyanoxyl-mediated polymerization of acrylamide with acrylate-derivatized mono- and disaccharides. We demonstrate that a glycopolymer bearing pendant, fully sulfated lactose units effectively replaces heparin and heparan sulfate as a molecular chaperone for fibroblast growth factor-2 (FGF-2). Specifically, a compound was identified that protects FGF-2 from proteolytic, acid, and heat-induced degradation, while selectively promoting growth factor and receptor dimerization. Significantly, the capacity of this heparin-mimic to promote an FGF-2 specific proliferative cell response was confirmed and suggests potential applications for this compound and related derivatives in areas related to therapeutic angiogenesis.

引用

收藏

页码：145 / 151

页数：7

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