3D-extravasation model -: selection of highly motile and metastatic cancer cells

被引：12

作者：

Brandt, B

Heyder, C

Gloria-Maercker, E

Hatzmann, W

Rötger, A

Kemming, D

Zänker, KS

Entschladen, F

Dittmar, T

机构：

[1] Univ Witten Herdecke, Inst Immunol, D-58448 Witten, Germany

[2] Univ Hamburg, Med Ctr, Ctr Med Expt, Inst Tumor Biol, D-20146 Hamburg, Germany

[3] Univ Witten Herdecke, Marien Hosp, Dept Gynecol, D-58453 Witten, Germany

[4] Carpegen, Munster, Germany

来源：

SEMINARS IN CANCER BIOLOGY | 2005年 / 15卷 / 05期

关键词：

metastasis; invasion; extravasation; cell-to-cell interactions;

D O I：

10.1016/j.semcancer.2005.06.006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Extravasation has been described as a rate-limiting step in the process of hematogeneous metastasis formation. Thereby, transendothelial migration of tumor cells consists of a complex series of events involving multiple cell-cell and cell-matrix interactions. 3D-extravasation assays are valuable tools for the identification of genes, which are the key players at switchboards of the intracellular signaling pathways. In consequence, the combination of 3D-modeling and whole genome expression analysis lead to unravel molecular parameters which descripe distinct clinical phenotypes of cancer and therefore, work as prognosticators, predictors of therapy and new therapy targets. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：387 / 395

页数：9

共 55 条

[1]

AKEDO H, 1989, INVAS METAST, V9, P134

[2] Intravascular origin of metastasis from the proliferation of endothelium-attached tumor cells: a new model for metastasis [J].