Synthesis of the pentasaccharide hapten from the glycopeptidolipid antigen of Mycobacterium avium serovar 17

被引：15

作者：

Varga, Z

Bajza, I

Batta, G

Lipták, A

机构：

[1] Univ Debrecen, Dept Biochem, H-4010 Debrecen, Hungary

[2] Hungarian Acad Sci, Res Grp Carbohydrates, H-4010 Debrecen, Hungary

[3] Hungarian Acad Sci, Res Grp Antibiot, H-4010 Debrecen, Hungary

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 31期

基金：

匈牙利科学研究基金会; 新加坡国家研究基金会;

关键词：

oligosaccharide; block synthesis; M. avium serovar 17; nilic acid; hapten; linker;

D O I：

10.1016/S0040-4039(01)00934-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Effective synthesis of the pentasaccharide hapten from the glycopeptidolipid antigen of Mycobacterium avium serovar 17 in a p-aminophenyl linker-containing form, using 3+2 block synthesis strategy, is described. A 2+3 block synthesis could not be achieved, although different glycosyl donors (1-Br, 1-SPh, 1-O-C(NH)CCl3) were used. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：5283 / 5286

页数：4

共 18 条

[1] The variable surface glycolipids of mycobacteria: Structures, synthesis of epitopes, and biological properties [J].