Linezolid resistance in a clinical isolate of Staphylococcus aureus

被引：845

作者：

Tsiodras, S

Gold, HS

Sakoulas, G

Eliopoulos, GM

Wennersten, C

Venkataraman, L

Moellering, RC

Ferraro, MJ

机构：

[1] Massachusetts Gen Hosp, Dept Pathol, Clin Microbiol Labs, Boston, MA 02114 USA

[2] Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA 02215 USA

[3] Beth Israel Deaconess Med Ctr, Dept Pathol, Boston, MA 02215 USA

[4] Massachusetts Gen Hosp, Dept Med, Boston, MA 02114 USA

[5] Harvard Univ, Sch Med, Boston, MA USA

来源：

LANCET | 2001年 / 358卷 / 9277期

关键词：

D O I：

10.1016/S0140-6736(01)05410-1

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The new oxazolidinone antimicrobial, linezolid, has been approved for the treatment of infections caused by various gram-positive bacteria, including meticillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE). Although instances of linezolid resistance in VRE have been reported, resistance has not been encountered among clinical isolates of S aureus. We have characterised an MRSA isolate resistant to linezolid that was recovered from a patient treated with this agent for dialysis-associated peritonitis.

引用

页码：207 / 208

页数：2

共 5 条

[1] Infections due to vancomycin-resistant Enterococcus faecium resistant to linezolid
Gonzales, RD
Schreckenberger, PC
Graham, MB
Kelkar, S
DenBesten, K
Quinn, JP
[J]. LANCET, 2001, 357 (9263) : 1179 - 1179
[2] The oxazolidinone linezolid inhibits initiation of protein synthesis in bacteria
Swaney, SM
Aoki, H
Ganoza, MC
Shinabarger, DL
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1998, 42 (12) : 3251 - 3255
[3] SWANEY SM, 1998, P 38 INT C ANT AG CH
[4] Rapid slide latex agglutination test for detection of methicillin resistance in Staphylococcus aureus
van Griethuysen, A
Pouw, M
van Leeuwen, N
Heck, M
Willemse, P
Buiting, A
Kluytmans, J
[J]. JOURNAL OF CLINICAL MICROBIOLOGY, 1999, 37 (09) : 2789 - 2792
[5] Oxazolidinone resistance mutations in 23S rRNA of Escherichia coli reveal the central region of domain V as the primary site of drug action
Xiong, LQ
Kloss, P
Douthwaite, S
Andersen, NM
Swaney, S
Shinabarger, DL
Mankin, AS
[J]. JOURNAL OF BACTERIOLOGY, 2000, 182 (19) : 5325 - 5331

← 1 →