Bioactive compounds from Rhodiola rosea (Crassulaceae)

被引：90

作者：

Ming, DS

Hillhouse, BJ

Guns, ES

Eberding, A

Xie, S

Vimalanathan, S

Towers, GHN

机构：

[1] Univ British Columbia, Fac Agr Sci, Dept Bot, Vancouver, BC V6T 1Z4, Canada

[2] Univ British Columbia, Dept Surg, Div Urol, Vancouver, BC V6T 1Z4, Canada

[3] Vancouver Gen Hosp, Prostate Ctr, Vancouver, BC V6H 3Z6, Canada

来源：

PHYTOTHERAPY RESEARCH | 2005年 / 19卷 / 09期

关键词：

Rhodiola rosea; gossypetin-7-O-L-rhamnopyranoside; rhodioflavonoside; gallic acid; trans-p-hydroxycinnamic acid; p-tyrosol; antibacterial; antiprostate cancer cell line;

D O I：

10.1002/ptr.1597

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The methanol extract of the underground part of Rhodiola rosea was found to show inhibitory activity against Staphylococcus aureus. Bioactivity-guided fractionation of a 95% ethanol extract from the stems of R. rosea led to the isolation of five compounds: gossypetin-7-O-L-rhamnopyranoside (1), rhodioflavonoside (2), gallic acid (3), trans-p-hydroxycinnamic acid (4) and p-tyrosol (5). Their structures were elucidated by UV, IR, MS and NMR data, as well as by comparison with those of the literature. Compounds 1 and 2 were evaluated for their antibacterial and antiprostate cancer cell activities. Compounds 1 and 2 exhibited activity against Staphylococcus aureus with minimum inhibitory concentrations of 50 mu g/mL and 100 mu g/mL, respectively. Cytotoxicity studies of I and 2 also displayed activity against the prostate cancer cell line with IC50 values of 50 mu g/mL and 80 mu g/mL, respectively. Copyright (c) 2005 John Wiley & Sons, Ltd.

引用

页码：740 / 743

页数：4