Brain atrophy associated with baseline and longitudinal measures of cognition

被引：112

作者：

Cardenas, V. A. ^{[1
,2
]}

Chao, L. L. ^{[1
,2
]}

Studholme, C. ^{[1
,2
]}

Yaffe, K. ^{[1
,2
]}

Miller, B. L. ^{[1
]}

Madison, C. ^{[3
]}

Buckley, S. T. ^{[2
]}

Mungas, D. ^{[4
]}

Schuff, N. ^{[1
,2
]}

Weiner, M. W. ^{[1
,2
]}

机构：

[1] Univ Calif San Francisco, Dept Vet Affairs Med Ctr, San Francisco, CA 94121 USA

[2] San Francisco VA Med Ctr, San Francisco, CA USA

[3] Calif Pacific Med Ctr, San Francisco, CA 94115 USA

[4] Univ Calif Davis, Davis, CA 95616 USA

来源：

NEUROBIOLOGY OF AGING | 2011年 / 32卷 / 04期

关键词：

Deformation morphometry; Longitudinal; Brain; MRI; Cognition; Memory; Executive function; VOXEL-BASED MORPHOMETRY; ALZHEIMERS-DISEASE; EXECUTIVE FUNCTION; QUANTITATIVE VALIDATION; INDIVIDUAL-DIFFERENCES; SEMANTIC KNOWLEDGE; OLDER PERSONS; IMPAIRMENT; DEMENTIA; MRI;

D O I：

10.1016/j.neurobiolaging.2009.04.011

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The overall goal was to identify patterns of brain atrophy associated with cognitive impairment and future cognitive decline in non-demented elders. Seventy-one participants were studied with structural MRI and neuropsychological testing at baseline and 1-year follow-up. Deformation-based morphometry was used to examine the relationship between regional baseline brain tissue volume with baseline and longitudinal measures of delayed verbal memory, semantic memory, and executive function. Smaller right hippocampal and entorhinal cortex (ERC) volumes at baseline were associated with worse delayed verbal memory performance at baseline while smaller left ERC volume was associated with greater longitudinal decline. Smaller left superior temporal cortex at baseline was associated with worse semantic memory at baseline, while smaller left temporal white and gray matter volumes were associated with greater semantic memory decline. Increased CSF and smaller frontal lobe volumes were associated with impaired executive function at baseline and greater longitudinal executive decline. These findings suggest that baseline volumes of prefrontal and temporal regions may underlie continuing cognitive decline due to aging, pathology, or both in non-demented elderly individuals. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：572 / 580

页数：9

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