Keratinocyte growth factor: A unique player in epithelial repair processes

被引：288

作者：

Werner, S ^{[1
]}

机构：

[1] Max Planck Inst Biochem, D-82152 Martinsried, Germany

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 1998年 / 9卷 / 02期

关键词：

keratinocyte growth factor; inflammation; repair; fibroblast growth factor; inflammatory disease; epidermis;

D O I：

10.1016/S1359-6101(98)00010-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Keratinocyte growth factor (KGF) is a member of the rapidly growing fibroblast growth factor (FGF) family of mitogens. Whereas most FGFs influence proliferation and/or differentiation of various cell types, KGF seems to act specifically on epithelial cells. It has been demonstrated that KGF stimulates proliferation and migration of these cells, but it also affects differentiation processes. Finally, recent studies have demonstrated a protective function of this growth factor in vitro and in vivo. Due to these properties, KGF could play an important role in repair processes. Indeed a series of studies have provided insight into the expression and function of KGF in inflammation and repair of various tissues and organs, and a therapeutic potential of this growth factor has been demonstrated. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：153 / 165

页数：13

共 108 条

[51] FGF-7 (KERATINOCYTE GROWTH-FACTOR) EXPRESSION DURING MOUSE DEVELOPMENT SUGGESTS ROLES IN MYOGENESIS, FOREBRAIN REGIONALIZATION AND EPITHELIAL-MESENCHYMAL INTERACTIONS [J].