A role for sex chromosome complement in the female bias in autoimmune disease

被引：265

作者：

Smith-Bouvier, Deborah L. ^{[2
]}

Divekar, Anagha A. ^{[1
]}

Sasidhar, Manda ^{[2
]}

Du, Sienmi ^{[2
]}

Tiwari-Woodruff, Seema K. ^{[2
]}

King, Jennifer K. ^{[1
]}

Arnold, Arthur P. ^{[3
]}

Singh, Ram Raj ^{[1
,4
]}

Voskuhl, Rhonda R. ^{[2
]}

机构：

[1] Univ Calif Los Angeles, Dept Med, Div Rheumatol, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Dept Neurol, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, Dept Physiol Sci, Los Angeles, CA 90095 USA

[4] Univ Calif Los Angeles, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2008年 / 205卷 / 05期

关键词：

D O I：

10.1084/jem.20070850

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Most autoimmune diseases are more common in women than in men. This may be caused by differences in sex hormones, sex chromosomes, or both. In this study, we determined if there was a contribution of sex chromosomes to sex differences in susceptibility to two immunologically distinct disease models, experimental autoimmune encephalomyelitis (EAE) and pristane-induced lupus. Transgenic SJL mice were created to permit a comparison between XX and XY within a common gonadal type. Mice of the XX sex chromosome complement, as compared with XY, demonstrated greater susceptibility to both EAE and lupus. This is the first evidence that the XX sex chromosome complement, as compared with XY, confers greater susceptibility to autoimmune disease.

引用

页码：1099 / 1108

页数：10

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