Asymmetric synthesis of seven-carbon segments of the phorboxazoles and (-)-discodermolide:: Complementary route from racemic trans-2,4-dimethyl-8-oxabicyclo[3.2.1]oct-6-en-3-one

被引：63

作者：

Misske, AM ^{[1
]}

Hoffmann, HMR ^{[1
]}

机构：

[1] Leibniz Univ Hannover, Dept Organ Chem, D-30167 Hannover, Germany

来源：

TETRAHEDRON | 1999年 / 55卷 / 14期

关键词：

D O I：

10.1016/S0040-4020(99)00127-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The C20-C26 segment of the phorboxazoles A and B and the C1-C7 segment of (-)-discodermolide were synthesized in excellent chemical and optical yield using trans-2,4-dimethyl-8-oxabicyclo[3.2.1]oct-6-en-3-one rac-1 with four stereogenic centres and three prostereogenic sp(2)-sites as an early racemic switch. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

引用

页码：4315 / 4324

页数：10

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