Clinical and Virologic Response to Episodic Acyclovir for Genital Ulcers Among HIV-1 Seronegative, Herpes Simplex Virus Type 2 Seropositive African Women: A Randomized, Placebo-Controlled Trial

被引：7

作者：

Baeten, Jared M. ^{[1
,2
,3
]}

Reid, Stewart E. ^{[4
,5
]}

Delany-Moretlwe, Sinead ^{[6
]}

Hughes, James P. ^{[7
]}

Wang, Richard S. ^{[1
]}

Wilcox, Ellen ^{[1
]}

Limbada, Mohammed ^{[5
]}

Akpomiemie, Godspower ^{[6
]}

Corey, Lawrence ^{[2
,8
,9
]}

Wald, Anna ^{[2
,3
,8
,9
]}

Celum, Connie ^{[1
,2
,3
]}

机构：

[1] Univ Washington, Dept Global Hlth, Seattle, WA 98104 USA

[2] Univ Washington, Dept Med, Seattle, WA 98104 USA

[3] Univ Washington, Dept Epidemiol, Seattle, WA 98104 USA

[4] Univ Alabama Birmingham, Dept Med, Birmingham, AL 35294 USA

[5] Ctr Infect Dis Res Zambia, Lusaka, Zambia

[6] Univ Witwatersrand, Sch Clin Med, Wits Inst Reprod Hlth & HIV, Johannesburg, South Africa

[7] Univ Washington, Dept Biostat, Seattle, WA 98104 USA

[8] Univ Washington, Dept Lab Med, Seattle, WA 98104 USA

[9] Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, Seattle, WA 98104 USA

来源：

SEXUALLY TRANSMITTED DISEASES | 2012年 / 39卷 / 01期

基金：

美国国家卫生研究院;

关键词：

ORAL ACYCLOVIR; DOUBLE-BLIND; SUPPRESSION; MEN; VALACYCLOVIR; ACQUISITION; INFECTION; EFFICACY; IMPACT; RNA;

D O I：

10.1097/OLQ.0b013e31823b50c6

中图分类号：

R51 [传染病];

学科分类号：

100201 [内科学];

摘要：

In a randomized trial among African women with recurrent genital herpes, episodic acyclovir therapy resulted in modestly greater likelihood of lesion healing (hazard ratio [HR] = 1.48, P = 0.098; mean, 5.1 vs. 6.0 days) and cessation of herpes simplex virus shedding (HR = 1.88, P = 0.008; mean, 3.0 vs. 5.0 days) compared with placebo, similar to results of studies in high-income countries (ClinicalTrials.gov registration NCT00808405).

引用

页码：21 / 24

页数：4

共 16 条

[1]

One-day regimen of valacyclovir for treatment of recurrent genital herpes simplex virus 2 infection [J].

Bavaro, Joseph B. ;

Drolette, Linda ;

Koelle, David M. ;

Almekinder, Jennifer ;

Warren, Terri ;

Tyring, Stephen ;

Wald, Anna .

SEXUALLY TRANSMITTED DISEASES, 2008, 35 (04) :383-386

[2]

TREATMENT OF 1ST EPISODES OF GENITAL HERPES-SIMPLEX VIRUS-INFECTION WITH ORAL ACYCLOVIR - A RANDOMIZED DOUBLE-BLIND CONTROLLED TRIAL IN NORMAL SUBJECTS [J].

BRYSON, YJ ;

DILLON, M ;

LOVETT, M ;

ACUNA, G ;

TAYLOR, S ;

CHERRY, JD ;

JOHNSON, BL ;

WIESMEIER, E ;

GROWDON, W ;

CREAGHKIRK, T ;

KEENEY, R .

NEW ENGLAND JOURNAL OF MEDICINE, 1983, 308 (16) :916-921

[3]

Effect of aciclovir on HIV-1 acquisition in herpes simplex virus 2 seropositive women and men who have sex with men: a randomised, double-blind, placebo-controlled trial [J].

Celum, Connie ;

Wald, Anna ;

Hughes, James ;

Sanchez, Jorge ;

Reid, Stewart ;

Delany-Moretlwe, Sinead ;

Cowan, Frances ;

Casapia, Martin ;

Ortiz, Abner ;

Fuchs, Jonathan ;

Buchbinder, Susan ;

Koblin, Beryl ;

Zwerski, Sheryl ;

Rose, Scott ;

Wang, Jing ;

Corey, Lawrence .

LANCET, 2008, 371 (9630) :2109-2119

[4]

Genital Ulcer Disease Treatment Policies and Access to Acyclovir in Eight Sub-Saharan African Countries [J].

Corbell, Catherine ;

Stergachis, Andy ;

Ndowa, Francis ;

Ndase, Patrick ;

Barnes, Linda ;

Celum, Connie .

SEXUALLY TRANSMITTED DISEASES, 2010, 37 (08) :488-493

[5]

Anonymous, 2006, Morbidity and Mortality Weekly Report, V55, P1

[6]

Herpes simplex virus 2 infection increases HIV acquisition in men and women: systematic review and meta-analysis of longitudinal studies [J].

Freeman, EE ;

Weiss, HA ;

Glynn, JR ;

Cross, PL ;

Whitworth, JA ;

Hayes, RJ .

AIDS, 2006, 20 (01) :73-83

[7]

Clinical and Virologic Efficacy of Herpes Simplex Virus Type 2 Suppression by Acyclovir in a Multicontinent Clinical Trial [J].

Fuchs, Jonathan ;

Celum, Connie ;

Wang, Jing ;

Hughes, James ;

Sanchez, Jorge ;

Cowan, Frances ;

Reid, Stewart ;

Delany-Moretlwe, Sinead ;

Corey, Lawrence ;

Wald, Anna .

JOURNAL OF INFECTIOUS DISEASES, 2010, 201 (08) :1164-1168

[8]

Valacyclovir and acyclovir for suppression of shedding of herpes simplex virus in the genital tract [J].

Gupta, R ;

Wald, A ;

Krantz, E ;

Selke, S ;

Warren, T ;

Vargas-Cortes, M ;

Miller, G ;

Corey, L .

JOURNAL OF INFECTIOUS DISEASES, 2004, 190 (08) :1374-1381

[9]

Quantitative stability of DNA after extended storage of clinical specimens as determined by real-time PCR [J].

Jerome, KR ;

Huang, ML ;

Wald, A ;

Selke, S ;

Corey, L .

JOURNAL OF CLINICAL MICROBIOLOGY, 2002, 40 (07) :2609-2611

[10]

Impact of Acyclovir on Genital and Plasma HIV-1 RNA, Genital Herpes Simplex Virus Type 2 DNA, and Ulcer Healing among HIV-1-Infected African Women with Herpes Ulcers: A Randomized Placebo-Controlled Trial [J].

Mayaud, Philippe ;

LeGoff, Jerome ;

Weiss, Helen A. ;

Gresenguet, Gerard ;

Nzambi, Khonde ;

Bouhlal, Hicham ;

Frost, Eric ;

Pepin, Jacques ;

Malkin, Jean-Elie ;

Hayes, Richard J. ;

Mabey, David C. W. ;

Belec, Laurent .

JOURNAL OF INFECTIOUS DISEASES, 2009, 200 (02) :216-226

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