Wnt signaling in disease and in development

被引：796

作者：

Nusse, R ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Howard Hughes Med Inst, Dept Dev Biol,Beckman Ctr, Stanford, CA 94305 USA

来源：

CELL RESEARCH | 2005年 / 15卷 / 01期

关键词：

cell signaling; Wnt proteins; adult tissue maintenance; human disease;

D O I：

10.1038/sj.cr.7290260

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The highly conserved Wnt secreted proteins are critical mediators of cell-to-cell signaling during development of animals. Recent biochemical and genetic analyses have led to significant insight into understanding how Wnt signals work. The catalogue of Wnt signaling components has exploded. We now realize that multiple extracellular, cytoplasmic, and nuclear components modulate Wnt signaling. Moreover, receptor-ligand specificity and multiple feedback loops determine Wnt signaling outputs. It is also clear that Wnt signals are required for adult tissue maintenance. Perturbations in Wnt signaling cause human degenerative diseases as well as cancer.

引用

页码：28 / 32

页数：5

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