Actinobacteria: the good, the bad, and the ugly

被引：72

作者：

Miao, Vivian ^{[1
]}

Davies, Julian ^{[1
]}

机构：

[1] Univ British Columbia, Dept Microbiol & Immunol, Vancouver, BC V5Z 1M9, Canada

来源：

ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY | 2010年 / 98卷 / 02期

基金：

加拿大健康研究院;

关键词：

Antibiotics; Bioactive molecules; Chemical diversity; Genomics; Molecular evolution; Natural products; Signaling; Therapeutics; MYCOBACTERIUM-TUBERCULOSIS; BIODEGRADATION; ANTIBIOTICS; RHODOCOCCUS; DISCOVERY;

D O I：

10.1007/s10482-010-9440-6

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The actinobacteria are arguably the richest source of small molecule diversity on the planet. These compounds have an incredible variety of chemical structures and biological activities (in nature and in the laboratory). Their potential for the development of therapeutic applications cannot be underestimated. It is suggested that an improved understanding of the biological roles of low molecular weight compounds in nature will lead to the discovery an inexhaustible supply of novel therapeutic agents in the next decade. To support this objective, a functional marriage of biochemistry, genomics, genetics, microbiology, and modern natural product chemistry will be essential.

引用

页码：143 / 150

页数：8

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