Heritability of free and receptor-bound leptin in normal twins

被引：16

作者：

Jordan, J

Brabant, G

Brinsuk, M

Tank, J

Horn, R

Luft, FC

Busjahn, A

机构：

[1] Humboldt Univ, Charite, Fac Med, Franz Volhard Clin Res Ctr, D-13125 Berlin, Germany

[2] HELIOS Klin, Berlin, Germany

[3] Hannover Med Sch, Dept Endocrinol, Hannover, Germany

[4] HealthTwiSt, Berlin, Germany

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY | 2005年 / 288卷 / 05期

关键词：

twin study; heritability; leptin; bound leptin;

D O I：

10.1152/ajpregu.00446.2004

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Free and receptor-bound leptin may be regulated by different mechanisms. Genes that influence the concentration of these fractions may have an important functional bearing. We determined circulating leptin receptor concentrations, bound as well as free leptin concentrations, and body composition in 24 monozygotic (MZ) and in 22 dizygotic (DZ) twin pairs. Bound leptin and leptin receptor concentrations were inversely correlated with body fat content. Free leptin concentrations were directly correlated with body fat content. The correlations in age- and sex-adjusted free leptin, bound leptin, and leptin receptor concentrations were higher between MZ twins than between DZ twins. Adjusted heritability (h2) estimates were 0.28 for free leptin, 0.73 for bound leptin, and 0.55 for leptin receptor. The genetic correlation with body fat was -0.58 for the leptin receptor, -0.20 for bound leptin, and 0.93 for free leptin. Our data are consistent with a strong genetic influence on leptin receptor and bound leptin and a weaker genetic influence on free leptin concentrations. The same genes that lower bound leptin and leptin receptor concentrations may increase fat mass or vice versa.

引用

页码：R1411 / R1416

页数：6

共 25 条

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