Regioselective cyclization of unsymmetrical dicyanoanilines to novel 2,3-bifunctionalised indole regioisomers and their use in the synthesis of 4,5-dihydro[1,3]oxazino[5,4-b]indole-6-carbonitriles

被引：17

作者：

Maitraie, D

Reddy, GV

Rao, VVVNSR

Ravikanth, S

Narsaiah, B ^{[1
]}

Rao, PS

Ravikumar, K

Sridhar, B

机构：

[1] Indian Inst Chem Technol, Fluoroorgan Div, Hyderabad 500007, Andhra Pradesh, India

[2] Indian Inst Chem Technol, Lab Xray Crystallog, Hyderabad 500007, Andhra Pradesh, India

来源：

TETRAHEDRON | 2005年 / 61卷 / 16期

关键词：

2,3-Bifunctionalised indole derivatives; 2,6-Dicyanoanilines; Ethyl bromoester; Regioisomers; Sandmeyer reaction; Substituted-iodobenzenes; Thorpe-Ziegler reaction;

D O I：

10.1016/j.tet.2005.02.046

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthesis of novel-2,3-bifunetionalised indole regioisomers (2/3 and 6/7) from unsymmetrical dicyanoanilines 1 by regioselective cyclization in two independent ways. Regioisomers 6 are further utilized in synthesis of novel 4,5-dihydro[1,3]oxazino[5,4-b] indole-6-carbonitriles 9. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：3999 / 4008

页数：10

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