Curcumin prevents the development of dextran sulfate sodium (DSS)-Induced experimental colitis

被引：97

作者：

Deguchi, Yasuyuki ^{[1
]}

Andoh, Akira ^{[1
]}

Inatomi, Osamu ^{[1
]}

Yagi, Yuhki ^{[1
]}

Bamba, Shigeki ^{[1
]}

Araki, Yoshio ^{[1
]}

Hata, Kazunori ^{[1
]}

Tsujikawa, Tomoyuki ^{[1
]}

Fujiyama, Yoshihide ^{[1
]}

机构：

[1] Shiga Univ Med Sci, Dept Internal Med, Otsu, Shiga 5202192, Japan

来源：

DIGESTIVE DISEASES AND SCIENCES | 2007年 / 52卷 / 11期

关键词：

inflammatory bowel disease; NF-kappa B; antioxidant; T cells;

D O I：

10.1007/s10620-006-9138-9

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Curcumin is a phenolic natural product isolated from the rhizome of Curcuma longa (turmeric). We evaluated the effects of curcumin on the development of dextran sulfate sodium (DSS)-induced experimental colitis. BALB/c mice were fed a chow containing either 3.5% (wt/wt) DSS or 3.5% DSS + 2.0% (wt/wt) curcumin. The body weight loss was more apparent in DSS-treated mice than in DSS + curcumin-treated mice. The disease activity index, histological colitis score, and MPO activity were all significantly higher in DSS-treated mice than in DSS plus curcumin-treated mice. Microscopically, mucosal edema, cellular infiltration, and epithelial disruption were much more severe in DSS-treated mice than in DSS + curcumin-treated mice. In DSS + curcumin-treated mice, NF-kappa B activation was blocked in the mucosa. In conclusion, the development of DSS-induced colitis was significantly attenuated by curcumin. Being a nontoxic natural dietary product, curcumin could be useful in treatment of IBD patients.

引用

页码：2993 / 2998

页数：6

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