Mx1-based resistance to Thogoto virus in A2G mice is bypassed in tick-mediated virus delivery

被引：12

作者：

Dessens, JT ^{[1
]}

Nuttall, PA ^{[1
]}

机构：

[1] NERC, Inst Virol & Environm Microbiol, Oxford OX1 3SR, England

来源：

JOURNAL OF VIROLOGY | 1998年 / 72卷 / 10期

关键词：

D O I：

10.1128/JVI.72.10.8362-8364.1998

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The interferon-induced mouse Mx1 protein has intrinsic antiviral activity against orthomyxoviruses, including Thogoto virus. Thus, Mx1(+) A2G mice are apparently resistant to infection following needle- or tick-borne virus challenge. However, tick-horne challenge and, to a lesser degree, injection of virus mixed with tick salivary gland extract resulted in virus transmission to uninfected ticks feeding on the A2G mice. The data indicate that immunomodulatory components in tick saliva can overcome a natural antiviral mechanism.

引用

页码：8362 / 8364

页数：3

共 16 条

[1] EXPERIMENTAL STUDIES ON THE TRANSMISSION CYCLE OF THOGOTO VIRUS, A CANDIDATE ORTHOMYXOVIRUS, IN RHIPICEPHALUS-APPENDICULATUS [J].

DAVIES, CR ;

JONES, LD ;

NUTTALL, PA .

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1986, 35 (06) :1256-1262

[2] Tick salivary gland extracts promote virus growth in vitro [J].

Hajnická, V ;

Fuchsberger, N ;

Slovák, M ;

Kocakova, P ;

Labuda, M ;

Nuttall, PA .

PARASITOLOGY, 1998, 116 :533-538

[3] TICK-BORNE THOGOTO VIRUS-INFECTION IN MICE IS INHIBITED BY THE ORTHOMYXOVIRUS RESISTANCE GENE-PRODUCT MX1 [J].

HALLER, O ;

FRESE, M ;

ROST, D ;

NUTTALL, PA ;

KOCHS, G .

JOURNAL OF VIROLOGY, 1995, 69 (04) :2596-2601

[4] INFLUENZA-VIRUS RESISTANCE OF WILD MICE - WILD-TYPE AND MUTANT MX ALLELES OCCUR AT COMPARABLE FREQUENCIES [J].

HALLER, O ;

ACKLIN, M ;

STAEHELI, P .

JOURNAL OF INTERFERON RESEARCH, 1987, 7 (05) :647-656

[5] MODIFICATION OF THE SKIN FEEDING SITE BY TICK SALIVA MEDIATES VIRUS TRANSMISSION [J].

JONES, LD ;

KAUFMAN, WR ;

NUTTALL, PA .

EXPERIENTIA, 1992, 48 (08) :779-782

[6] A NOVEL MODE OF ARBOVIRUS TRANSMISSION INVOLVING A NONVIREMIC HOST [J].

JONES, LD ;

DAVIES, CR ;

STEELE, GM ;

NUTTALL, PA .

SCIENCE, 1987, 237 (4816) :775-777

[7] Amblyomma variegatum (Acari: Ixodidae): Mechanism and control of arbovirus secretion in tick saliva [J].

Kaufman, WR ;

Nuttall, PA .

EXPERIMENTAL PARASITOLOGY, 1996, 82 (03) :316-323

[8] INHIBITION OF INFLUENZA VIRAL MESSENGER-RNA SYNTHESIS IN CELLS EXPRESSING THE INTERFERON-INDUCED MX GENE-PRODUCT [J].

KRUG, RM ;

SHAW, M ;

BRONI, B ;

SHAPIRO, G ;

HALLER, O .

JOURNAL OF VIROLOGY, 1985, 56 (01) :201-206

[9] Importance of localized skin infection in tick-borne encephalitis virus transmission [J].

Labuda, M ;

Austyn, JM ;

Zuffova, E ;

Kozuch, O ;

Fuchsberger, N ;

Lysy, J ;

Nuttall, PA .

VIROLOGY, 1996, 219 (02) :357-366

[10] RESISTANCE OF MICE TO MOUSE-ADAPTED INFLUENZA A VIRUS [J].

LINDENMANN, J .

VIROLOGY, 1962, 16 (02) :203-&

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