Mx1-based resistance to Thogoto virus in A2G mice is bypassed in tick-mediated virus delivery

被引：12

作者：

Dessens, JT ^{[1
]}

Nuttall, PA ^{[1
]}

机构：

[1] NERC, Inst Virol & Environm Microbiol, Oxford OX1 3SR, England

来源：

JOURNAL OF VIROLOGY | 1998年 / 72卷 / 10期

关键词：

D O I：

10.1128/JVI.72.10.8362-8364.1998

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The interferon-induced mouse Mx1 protein has intrinsic antiviral activity against orthomyxoviruses, including Thogoto virus. Thus, Mx1(+) A2G mice are apparently resistant to infection following needle- or tick-borne virus challenge. However, tick-horne challenge and, to a lesser degree, injection of virus mixed with tick salivary gland extract resulted in virus transmission to uninfected ticks feeding on the A2G mice. The data indicate that immunomodulatory components in tick saliva can overcome a natural antiviral mechanism.

引用

页码：8362 / 8364

页数：3

共 16 条

[11]

NUTTALL PA, 1994, J MED ENTOMOL, V31, P1, DOI 10.1093/jmedent/31.1.1

[12] Displaced tick-parasite interactions at the host interface [J].

Nuttall, PA .

PARASITOLOGY, 1998, 116 :S65-S72

[13] Virus taxonomy 1996 - A bulletin from the 10th International Congress of Virology in Jerusalem [J].

Pringle, CR .

ARCHIVES OF VIROLOGY, 1996, 141 (11) :2251-2256

[14]

Staeheli Peter, 1993, Trends in Cell Biology, V3, P268, DOI 10.1016/0962-8924(93)90055-6

[15] Male ticks help their mates to feed [J].

Wang, H ;

Paesen, GC ;

Nuttall, PA ;

Barbour, AG .

NATURE, 1998, 391 (6669) :753-754

[16] Tick-host immunology: Significant advances and challenging opportunities [J].

Wikel, SK ;

Bergman, D .

PARASITOLOGY TODAY, 1997, 13 (10) :383-389

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