A decade of molecular cell biology: achievements and challenges

被引:20
作者
Akhtar, Asifa [1 ]
Fuchs, Elaine [2 ]
Mitchison, Tim [3 ]
Shaw, Reuben J. [4 ]
St Johnston, Daniel [5 ]
Strasser, Andreas [6 ]
Taylor, Susan [7 ]
Walczak, Claire [8 ]
Zerial, Marino [9 ]
机构
[1] Max Planck Inst Immunobiol & Epigenet, D-79108 Freiburg, Germany
[2] Rockefeller Univ, Howard Hughes Med Inst, New York, NY 10065 USA
[3] Harvard Univ, Dept Syst Biol, Sch Med, Boston, MA 02115 USA
[4] Salk Inst Biol Studies, La Jolla, CA 92037 USA
[5] Univ Cambridge, Wellcome Trust Canc Res UK Gurdon Inst, Cambridge CB2 1QN, England
[6] Walter & Eliza Hall Inst Med Res, Canc Div, Melbourne, Vic 3050, Australia
[7] Univ Calif San Diego, Howard Hughes Med Inst, La Jolla, CA 92093 USA
[8] Indiana Univ, Bloomington, IN 47405 USA
[9] Max Planck Inst Mol Cell Biol & Genet MPI CBG, D-01307 Dresden, Germany
基金
英国惠康基金;
关键词
MICROSCOPY;
D O I
10.1038/nrm3187
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Nature Reviews Molecular Cell Biology celebrated its 10-year anniversary during this past year with a series of specially commissioned articles. To complement this, here we have asked researchers from across the field for their insights into how molecular cell biology research has evolved during this past decade, the key concepts that have emerged and the most promising interfaces that have developed. Their comments highlight the broad impact that particular advances have had, some of the basic understanding that we still require, and the collaborative approaches that will be essential for driving the field forward.
引用
收藏
页码:669 / +
页数:6
相关论文
共 8 条
[1]   Imaging intracellular fluorescent proteins at nanometer resolution [J].
Betzig, Eric ;
Patterson, George H. ;
Sougrat, Rachid ;
Lindwasser, O. Wolf ;
Olenych, Scott ;
Bonifacino, Juan S. ;
Davidson, Michael W. ;
Lippincott-Schwartz, Jennifer ;
Hess, Harald F. .
SCIENCE, 2006, 313 (5793) :1642-1645
[2]   Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation [J].
Chapman, Paul B. ;
Hauschild, Axel ;
Robert, Caroline ;
Haanen, John B. ;
Ascierto, Paolo ;
Larkin, James ;
Dummer, Reinhard ;
Garbe, Claus ;
Testori, Alessandro ;
Maio, Michele ;
Hogg, David ;
Lorigan, Paul ;
Lebbe, Celeste ;
Jouary, Thomas ;
Schadendorf, Dirk ;
Ribas, Antoni ;
O'Day, Steven J. ;
Sosman, Jeffrey A. ;
Kirkwood, John M. ;
Eggermont, Alexander M. M. ;
Dreno, Brigitte ;
Nolop, Keith ;
Li, Jiang ;
Nelson, Betty ;
Hou, Jeannie ;
Lee, Richard J. ;
Flaherty, Keith T. ;
McArthur, Grant A. .
NEW ENGLAND JOURNAL OF MEDICINE, 2011, 364 (26) :2507-2516
[3]   Midzone activation of aurora B in anaphase produces an intracellular phosphorylation gradient [J].
Fuller, Brian G. ;
Lampson, Michael A. ;
Foley, Emily A. ;
Rosasco-Nitcher, Sara ;
Le, Kim V. ;
Tobelmann, Page ;
Brautigan, David L. ;
Stukenberg, P. Todd ;
Kapoor, Tarun M. .
NATURE, 2008, 453 (7198) :1132-U14
[4]   Visualization of a Ran-GTP gradient in interphase and mitotic Xenopus egg extracts [J].
Kalab, P ;
Weis, K ;
Heald, R .
SCIENCE, 2002, 295 (5564) :2452-2456
[5]   Fluorescence microscopy with diffraction resolution barrier broken by stimulated emission [J].
Klar, TA ;
Jakobs, S ;
Dyba, M ;
Egner, A ;
Hell, SW .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (15) :8206-8210
[6]   Melanomas acquire resistance toB-RAF(V600E) inhibition by RTK or N-RAS upregulation [J].
Nazarian, Ramin ;
Shi, Hubing ;
Wang, Qi ;
Kong, Xiangju ;
Koya, Richard C. ;
Lee, Hane ;
Chen, Zugen ;
Lee, Mi-Kyung ;
Attar, Narsis ;
Sazegar, Hooman ;
Chodon, Thinle ;
Nelson, Stanley F. ;
McArthur, Grant ;
Sosman, Jeffrey A. ;
Ribas, Antoni ;
Lo, Roger S. .
NATURE, 2010, 468 (7326) :973-U377
[7]   Sub-diffraction-limit imaging by stochastic optical reconstruction microscopy (STORM) [J].
Rust, Michael J. ;
Bates, Mark ;
Zhuang, Xiaowei .
NATURE METHODS, 2006, 3 (10) :793-795
[8]   Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors [J].
Takahashi, Kazutoshi ;
Yamanaka, Shinya .
CELL, 2006, 126 (04) :663-676