In vivo bioimaging using photogenic rats:: Fate of injected bone marrow-derived mesenchymal stromal cells

被引：39

作者：

Hara, Mayumi ^{[1
]}

Murakami, Takashi ^{[1
]}

Kobayashi, Eiji ^{[1
]}

机构：

[1] Jichi Med Univ, Ctr Mol Med, Div Organ Replacement Res, Jichi Med Sch, Shimotsuke, Tochigi 3290498, Japan

来源：

JOURNAL OF AUTOIMMUNITY | 2008年 / 30卷 / 03期

关键词：

transgenic rat; luciferase; luminescent imaging; chemokine receptors;

D O I：

10.1016/j.jaut.2007.12.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mesenchymal stromal cells (MSCs) derived from bone marrow have the capacity for self-renewal and differentiation, and can give rise to cells of a muscle, bone, fat or cartilage lineage. Based on this potential and feasibility, MSCs are expected to be used in cell therapy for human diseases. Intriguingly, MSCs migrate to various in vivo locations, including injury and tumor sites. However, their cellular fate and distribution remain unclear. In this review, we first describe the potential of a photogenic transgenic rat that expresses fluorescent and/or luminescent proteins (e.g., green fluorescent protein and luciferase), and then focus on the characteristic migration of MSCs to injury and tumor sites. In addition, we will discuss an efficient delivery method for targeting the injured site. Synergized with modem advances in optical imaging, the photogenic rat system provides innovative preclinical tools and a new platform on which to further our understanding of matters concerning stem cell biology. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：163 / 171

页数：9

共 79 条

[1] Bone marrow stem cell transplant into intra-bone cavity prevents type 2 diabetes: Role of heme oxygenase-adiponectin
Abraham, Nader G.
Li, Ming
Vanella, Luca
Peterson, Stephen J.
Ikehara, Susumu
Asprinio, David
[J]. JOURNAL OF AUTOIMMUNITY, 2008, 30 (03) : 128 - 135
[2] Genealogies of mouse inbred strains
Beck, JA
Lloyd, S
Hafezparast, M
Lennon-Pierce, M
Eppig, JT
Festing, MFW
Fisher, EMC
[J]. NATURE GENETICS, 2000, 24 (01) : 23 - +
[3] BERESFORD JN, 1992, J CELL SCI, V102, P341
[4] Beyer Nardi N, 2006, HANDB EXP PHARM, V174, P249
[5] Marrow stromal stem cells
Bianco, P
Robey, PG
[J]. JOURNAL OF CLINICAL INVESTIGATION, 2000, 105 (12) : 1663 - 1668
[6] The evolving concept of a stem cell: Entity or function?
Blau, HM
Brazelton, TR
Weimann, JM
[J]. CELL, 2001, 105 (07) : 829 - 841
[7] The emergence of progressive multifocal leukoencephalopathy (PML) in rheumatic diseases
Boren, Eric J.
Cheema, Gurtej S.
Naguwa, Stanley M.
Ansari, Aftab A.
Gershwin, M. Eric
[J]. JOURNAL OF AUTOIMMUNITY, 2008, 30 (1-2) : 90 - 98
[8] From marrow to brain: Expression of neuronal phenotypes in adult mice
Brazelton, TR
Rossi, FMV
Keshet, GI
Blau, HM
[J]. SCIENCE, 2000, 290 (5497) : 1775 - 1779
[9] A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development
Burns, Jennifer M.
Summers, Bretton C.
Wang, Yu
Melikian, Anita
Berahovich, Rob
Miao, Zhenhua
Penfold, Mark E. T.
Sunshine, Mary Jean
Littman, Dan R.
Kuo, Calvin J.
Wei, Kevin
McMaster, Brian E.
Wright, Kim
Howard, Maureen C.
Schall, Thomas J.
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2006, 203 (09) : 2201 - 2213
[10] Hematopoietic stem cell transplantation for autoimmune diseases: What have we learned?
Burt, Richard K.
Testor, Alessandro
Craig, Robert
Cohen, Bruce
Suffit, Robert
Barr, Walter
[J]. JOURNAL OF AUTOIMMUNITY, 2008, 30 (03) : 116 - 120

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