Effect of gemfibrozil on serum levels of prostacyclin and precursor fatty acids in hyperlipidemic patients with type 2 diabetes

被引：14

作者：

Yoshinari, M ^{[1
]}

Asano, T ^{[1
]}

Kaori, S ^{[1
]}

Shi, AH ^{[1
]}

Wakisaka, M ^{[1
]}

Iwase, M ^{[1
]}

Fujishima, M ^{[1
]}

机构：

[1] Kyushu Univ, Fac Med, Dept Internal Med 2, Fukuoka 8128582, Japan

来源：

DIABETES RESEARCH AND CLINICAL PRACTICE | 1998年 / 42卷 / 03期

关键词：

gemtibrozil; prostacyclin; fatty acids; type 2 diabetes mellitus;

D O I：

10.1016/S0168-8227(98)00107-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Lipid-lowering fibrate drugs are known to affect the synthesis of fatty acids, which may alter the prostacyclin synthesis in diabetic patients. Therefore, the serum levels of precursor fatty acids and 6-keto-prostaglandin F-1 alpha (6-keto PGF(1 alpha)) were determined in ten hyperlipidemic patients with Type 2 diabetes before and after administration of gemfibrozil (900 mg/day) for 3 months, in comparison with the results in seven non-diabetic hyperlipidemic patients. Gemfibrozil significantly reduced the serum concentration of dihomo-gamma-linolenic acid, total cholesterol and triglycerides, but did not affect the serum levels of arachidonic acid and 6-keto PGF(1 alpha) in diabetic and non-diabetic patients. Thus, gemfibrozil did not affect the synthesis of prostacyclin in spite of the reduction of precursor fatty acids in diabetic and non-diabetic patients. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：149 / 154

页数：6

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