The development of nociceptive circuits

被引:522
作者
Fitzgerald, M [1 ]
机构
[1] UCL, Dept Anat & Dev Biol, Wellcome Pain Consortium, London WC1E 6BT, England
基金
英国惠康基金;
关键词
D O I
10.1038/nrn1701
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The study of pain development has come into its own. Reaping the rewards of years of developmental and molecular biology, it has now become possible to translate fundamental knowledge of signalling pathways and synaptic physiology into a better understanding of infant pain. Research has cast new light on the physiological and pharmacological processes that shape the newborn pain response, which will help us to understand early pain behaviour and to design better treatments. Furthermore, it has shown how developing pain circuitry depends on non- noxious sensory activity in the healthy newborn, and how early injury can permanently alter pain processing.
引用
收藏
页码:507 / 520
页数:14
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