Cancer-promoting tumor-associated macrophages: New vistas and open questions

被引：172

作者：

Mantovani, Alberto ^{[1
]}

Germano, Giovanni ^{[1
]}

Marchesi, Federica ^{[1
]}

Locatelli, Marco ^{[2
]}

Biswas, Subhra K. ^{[3
]}

机构：

[1] Univ Milan, Ist Clin Humanitas IRCCS, I-20089 Rozzano, Italy

[2] Univ Milan, Dept Neurosurg, Fdn IRCCS Ca Granda Osped Maggiore Policlin, Milan, Italy

[3] Singapore Immunol Network, Agcy Sci Technol & Res, Singapore, Singapore

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 2011年 / 41卷 / 09期

关键词：

Cancer; Chemokines; Inflammation; Macrophages; Tumor-associated macrophages; CD4(+) T-CELLS; POLARIZATION; PROLIFERATION; INFLAMMATION; PROGRESSION; METASTASIS; MONOCYTES; RITUXIMAB; ANTITUMOR; SUBSETS;

D O I：

10.1002/eji.201141894

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Tumor-associated macrophages (TAMs) are key components of the tumor macroenvironment. Cancer- and host cell-derived signals generally drive the functions of TAMs towards an M2-like polarized, tumor-propelling mode; however, when appropriately re-educated. TAMs also have the potential to elicit tumor destructive reactions. Here, we discuss recent advances regarding the immunobiology of TAMs and highlight open questions including the mechanisms of their accumulation (recruitment versus proliferation), their diversity and how to best therapeutically target these cells.

引用

页码：2522 / 2525

页数：5

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